Featured Articles

Z. Wang, S. Liu, M. Kakizaki, Y. Hirose, Y. Ishikawa, H. Funato, M. Yanagisawa, Y. Yu, Q. Liu. Orexin/Hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calciumstimulated lysosome v-ATPase pathway. J Biol Chem, 289: 31950-31959. PMCID4231673 (2014)

X. Ye, N. Huang, Y. Liu, Z. Paroo, C. Huerta, P. Li, S. Chen, Q. Liu*, H. Zhang* (co-corresponding authors). Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol. 18:650-657 (2011)

Y. Liu, X. Ye, F. Jiang, C. Liang, D. Chen, J. Peng, L.N. Kinch, N.V. Grishin, and Q. Liu. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science,325:750-753 (2009)

Paroo, X. Ye, S. Chen, and Q. Liu. Phosphorylation of the human micro-RNA generating complex mediates MAPK/Erk signaling. Cell 139:112-122 (2009)

F. Jiang, X. Ye, X. Liu, L. Fincher, D. McKearin, Q. Liu, Dicer-1 and R3D1-L catalyze miRNA maturation in Drosophila. Genes Dev 19: 1674-1679 (2005).

Q. Liu, T. A. Rand, S. Kalidas, F. Du, H. Kim, D.P. Smith, X. Wang, R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301:1921-1925. (2003) (Previewed in Cell 115: 132-133).

Q. Liu, M. Z. Li, D. Liebham, D. Cortez, S. J. Elledge, The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Curr Biol 8:1300-1309 (1998). (Preview in Science 283: 349, 1999).

Peer Reviewed Research Articles

H. Funato, C. Miyoshi, T. Fujiyama, T. Kanda, M. Sato, Z. Wang, J. Ma, S. Nakane, J. Tomita, A. Ikkyu, M. Kakizaki, N. Hotta-Hirashima, S. Kanno, H. Komiya, F. Asano, T. Honda, S. Kim, K. Harano, H. Muramoto, T. Yonezawa, S. Mizuno, S. Miyazaki, L. Connor, V. Kumar, I. Miura, T. Suzuki, A. Watanabe, M. Abe, F. Sugiyama, S. Takahashi, K. Sakimura, Y. Hayashi, Q. Liu, K. Kume, S. Wakana, J. Takahashi, M. Yanagisawa. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 593:378-383. (2016)

H. Liu, C. Liang, RK. Kollipara, M. Matsui, X. Ke, BC. Jeong, Z. Wang, KS. Yoo, G. Yadav, L. Kinch, N. Grishin, Y. Nam, D. Corey, R. Kittler, Q. Liu. HP1BP3, a chromatin retention factor for co-transcriptional microRNA processing. Molecular Cell, 63:420-432. (2016)

C. Liang, Y. Wang, Y. Murota, X. Liu, D. Smith, MC. Siam, Q. Liu. TAF11 assembles the RISC loading complex to enhance RNAi efficiency. Molecular Cell, 59:807-818. (2015)

J. Hands, H. Zhang, DH. Chen, Q. Zhou, P. Jin, Q. Liu, S. Wang. Gossypol acetic acid prevents oxidative stress-induced retinal pigment epithelial necrosis by regulating the FoxO3/Sestrin2 pathway. Molecular and Cellular Biology, 35:1952-1963. (2015)

Z. Wang, S. Liu, M. Kakizaki, Y. Hirose, Y. Ishikawa, H. Funato, M. Yanagisawa, Y. Yu, Q. Liu. Orexin/Hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calciumstimulated lysosome v-ATPase pathway. J Biol Chem, 289: 31950-31959. PMCID4231673 (2014)

MC. Llaguno, H. Xu, L. Shi, N. Huang, H. Zhang, Q. Liu, QX. Jiang. Chemically functionalized carbon films for single molecule imaging. J. Struc Biol. 185:405-417. PMCID3990355 (2014)

Karamyshev AL, Patrick AE, Karamysheva ZN, Griesemer DS, Hudson H, Tjon-Kon-Sang S, Nilsson I, Otto H, Liu Q, Rospert S, von Heijne G, Johnson AE, Thomas PJ. Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway. Cell 156: 146-157 (2014)

C. Liang, K. Xiong, K.E. Szulwuch, Y. Zhang, Z. Wang, J. Peng, M. Fu, P. Jing, H.I. Suzuki, Q. Liu. Sjogren Syndrome Antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition. J Biol Chem, 288:723-36 PMCID3537071 (2013)

L. Li, W. Gu, C. Liang, Q. Liu, C.C. Mello, Y. Liu. The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing. Nat Struct Mol Biol. 19:824-30. PMCID3414638 (2012)

Y. Li, L. Lin, Z. Li, X. Ye, K. Xiong, B. Aryal, Z. Xu, Z. Paroo, Q. Liu, C. He, P. Jin (2012) Iron Homeostasis Regulates the Activity of the MicroRNA Pathway through Poly(C)-Binding Protein 2. Cell Metabolism, 15:895-904 (2012)

Y. Liu, H. Tan, H. Tian, C. Liang, S. Chen, Q. Liu. Autoantigen La promotes RNAi, antiviral response, and transposon silencing by facilitating multi-turnover RISC catalysis, Mol Cell 44:502-8 (2011).

X. Ye, N. Huang, Y. Liu, Z. Paroo, C. Huerta, P. Li, S. Chen, Q. Liu*, H. Zhang* (co-corresponding authors). Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol. 18:650-657 (2011)

N. Welker, T.S. Maity*, X. Ye*, P.J. Aruscavage, A.A. Krauchuk, Q. Liu, and B.L. Bass. Dicer’s helicase domain discriminates dsRNA termini to promote an altered reaction mode. Mol Cell 41: 589-599 (2011).

K. Okamura, N. Robine, Y. Liu, Q. Liu, and E.C. Lai. R2D2 organizes small regulatory RNA pathways in Drosophila. Mol Cell Biol 31:884-896. PMCID3028645 (2011).

M. Yoda, T. Kawamata, Z. Paroo, X. Ye, S. Iwasaki, Q. Liu, and Y. Tomari. ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol 17:17-23. PMCID2915567 (2010).

Paroo, X. Ye, S. Chen, and Q. Liu. Phosphorylation of the human micro-RNA generating complex mediates MAPK/Erk signaling. Cell 139:112-122 (2009)

Y. Liu, X. Ye, F. Jiang, C. Liang, D. Chen, J. Peng, L.N. Kinch, N.V. Grishin, and Q. Liu. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science,325:750-753 (2009)

Shan G, Li Y, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan AW, Shi Z, Liu Q, Wahlestedt C, He C, Jin P, A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol 26:933-940 (2008)

S. Kalidas, C, Sanders, X Ye, T Strauss, M Kuhn, Q. Liu, D. Smith, Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1. Mech Dev 125:475-85 (2008)

X. Liu, J. Park, F. Jiang, Y. Liu, D. McKearin, and Q. Liu, Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes. RNA 13: 2324-2329 (2007).

X. Ye, Z. Paroo, and Q. Liu, The functional anatomy of Drosophila microRNA-generating enzyme. J Biol Chem 282: 28373-28378 (2007).

S. Choudhary, H.C.Lee, M. Maiti, P. Cheng, Q. Liu, Y. Liu, A double-stranded RNA response program important for RNAi efficiency. Mol Cell Biol 27: 3995-4005 (2007). (Cover Story).

K. Zaugg, Y. Su, P. T. Reilly, Y. Moolani, C. C. Cheung, R. Hakem, A. Hirao, Q. Liu, S. J. Elledge, and T. W. Mak, Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. PNAS 104: 3805-3810 (2007).

J. Park, X. Liu, T. Strauss, D. McKearin, and Q. Liu, The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells. Curr Biol 17: 533–538(2007). (Cover story).

X. Liu, F. Jiang, K. Savitha, D. Smith, Q. Liu, Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes. RNA 12:1514-1520 (2006).

F. Jiang, X. Ye, X. Liu, L. Fincher, D. McKearin, Q. Liu, Dicer-1 and R3D1-L catalyze miRNA maturation in Drosophila. Genes Dev 19: 1674-1679 (2005).

M. L. Lam, Q. Liu, S. J. Elledge, J. M. Rosen, Haplo-insufficency for Chk1 results in a damage S phase and cell cycle mis-coordination during development. Cancer Cell 6:45-59 (2004).

Q. Liu, T. A. Rand, S. Kalidas, F. Du, H. Kim, D.P. Smith, X. Wang, R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301:1921-1925. (2003) (Previewed in Cell 115: 132-133).

Q. Liu et al., Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev 14: 1448-1459 (2000).

Q. Liu, M. Z. Li, D. Liebham, D. Cortez, S. J. Elledge, The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Curr Biol 8:1300-1309 (1998). (Preview in Science 283: 349, 1999).

Y. Sanchez, B. A. Desany, W. J. Jones, Q. Liu, B. Wang, S. J. Elledge, Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271: 357-360 (1996).

Invited Review and Book Chapters

Q. Liu and Z. Paroo, Biochemical and regulatory mechanisms of small RNA pathways. Annu Y. Liu and Q. Liu, ATM signals miRNA biogenesis through KSRP. Mol Cell, 41: 367-8 (2011)

Q. Liu and Z. Paroo. Dicer’s cut and switch. Science, 328:314-5 (2010).

Q. Liu and Z. Paroo, Biochemical and regulatory mechanisms of small RNA pathways. Annu Rev Biochem, 79: 295-319 (2010)

X. Ye and Q. Liu, Expression, purification, and analysis of recombinant Drosophila Dicer1 and Dicer2 enzymes. Methods Mol Biol 442:11-27 (2008).

Z. Paroo, Q. Liu, X. Wang, Biochemical mechanisms of the RNA-induced silencing complex. Cell Res 17: 187-194 (2007).

Q. Liu, M.Z. Li, D. Liu, S.J. Elledge, Rapid construction of recombinant DNA by the univector plasmid-fusion system. Methods Enzymol 328: 530-549 (2000).